Student t-tests were performed to compare miR-34a expression level between classes in TCGA data, with P < 0.05 considered significant. To identify mRNA expression patterns that significantly correlate with miR-34 expression, a Pearson’s correlation was performed, and p-values were corrected using false discovery rate (FDR) and Bonferroni methods. For experimental data, Parametric Student’s t test or Mann-Whitney U test were performed for comparing two groups. Data are demonstrated as mean ± standard error of mean (SEM) or standard deviation (SD). P values less than 0.05 were considered as statistically significant.

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