Jha et al. reported that the score of reflux symptoms in GSRS in patients with GERD were improved by 40% with administration of ramelteon (8 mg per day) for 4 weeks; therefore, we have assumed that dyspepsia symptoms in mFSSG in patients with FD will also be improved by 40% with sleep aids [9]. With a standard deviation of 0.5, a power of 80%, and level of significance of 5% using the paired t-test, it was calculated that a sample size of 15 is needed. A total of 25% of patients could be excluded from the study, meaning that 20 patients were required for the purposes of the present study.

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