Specimens were fixed using 10% neutral buffered formalin, paraffin embedded, and then stained with hematoxylin and eosin (HE). The histological subtypes of lung adenocarcinomas were evaluated using the 2015 WHO classification criteria [5]. Each histological component was recorded in 5% increments. The tumours were categorized by their main pattern: lepidic predominant adenocarcinoma (LP), acinar predominant adenocarcinoma (AP), papillary predominant adenocarcinoma (PP), micropapillary predominant adenocarcinoma (MP), and solid predominant adenocarcinoma (SP).

CHA and nonmucinous lepidic components were used as complementary approaches. SMLC can be considered SMPLC if the following four criteria are met: (1) differences in major histology subtype, (2) at least one tumours has beeen diagnosed as AIS, (3) a low grade lepidic component is present in all tumours, (4) similar major histology subtype but differences in other histology subtypes.

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