The outcomes will be presented as the mean differences (MDs)/standardized mean differences (SMDs) with 95% confidence intervals (CI) unless otherwise stated for continuous variable. For dichotomous data, the effect estimate is risk ratios (RRs) with 95% CI. If there is strong evidence of homogeneous effects through findings, using a model of random effects we will mainly sum up a low probability of bias results. The meta-analysis of random effects will be viewed with due consideration of the full range of outcomes, preferably by providing an interval of predictions. In each study, the predicted range for the true treatment effect will be specified using the prediction interval. The quality of evidence of the included studies in the review will be assessed using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system. This system grades quality of evidence at 4 levels: high (4), moderate (3), low (2), and very low (1) [33].

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