In order to classify the DEGs (both up- and down-regulated) according to its functional annotation, genes were imported into the web-tool Protein ANalysis Through Evolutionary Relationships (PANTHER) classification system (version 13.0) (41). This web resource allows understanding the biological meaning behind large list of DEGs based on their GO classification. For the enrichment analysis, the major over-represented GO were chosen according to a p-value < 0.05 criteria (biological processes; cellular component). The biological interpretation of the DEGs obtained was complemented using the free access databases GeneCards (www.genecards.org) (42) and UniProt (www.uniprot.org) (43).

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