Sociodemographic information (age, sex, and race) and HIV transmission risk (men who have sex with men [MSM], people who inject drugs [PWID], heterosexual contact, and other or unknown) were collected through self-report or medical record review at enrollment. Individuals who were both MSM and PWID (1229 individuals [1.1%]) were categorized as PWID. Antiretroviral regimens were characterized at beginning of each cART era. CD4 cell counts (cells per microliter) were measured at the time closest to entry of each cART era or beginning of cancer observation within that period. HIV RNA levels (copies per milliliter) were measured 2 years (18-30 months) before HCC diagnosis or censoring (loss-to-follow-up or end of observation). FIB-4 (fibrosis-4) scores were calculated using standard methods based on studies conducted in patients with chronic hepatitis, with a value greater than 3.25 considered advanced liver fibrosis.25

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