For each novel region, we defined sets of credible causal variants (CCVs) to use in the prediction of the likely target genes. For this purpose, we defined a first set of CCVs including the top SNP of the region of interest and the SNPs with p-values of association within two orders of magnitude of the top SNP association. Then, we sequentially performed logistic regression analyses using all other SNPs in the region, adjusted for the top SNP. We defined a second set of CCVs which included the most significant SNP after adjusting for the top SNP and the SNPs with p-values within two orders of magnitude of the most significant SNP association. This was repeated (conditioning on the previously found most significant SNPs) to define additional sets of CCVs as long as at least one p-value remained <10−6.

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