These criteria applied to participants consented and did not withdraw from the study at any time-point of C-LACE study:

Patients’ recruitment rate: as per Birmingham Women’s Hospital Caesarean Section rate, recruitment of 30 patients would be achievable easily within 3 months. If this was not achieved, the protocol (specific inclusion and exclusion criteria) would be reviewed and reassessed.

Collecting samples: this pilot and feasibility study would be considered successful if plasma and adipose tissue samples at the time of incision and time of closure and plasma sample at time of recovery were successfully collected for ≥ 75% of participant in each arm. If this was not achievable, the sampling strategies will be revised and reassessed.

Sample analysis: this pilot and feasibility study would be considered successful if ≥ 80% of plasma and adipose tissue samples collected were successfully analysed via the analytical method described; If not, sampling handling, transferring and sample analysis protocol will be revised and reassessed.

Data collecting: this pilot and feasibility study would be considered successful if ≥ 80% of data collecting forms was fulfilled for each participant; if not, logistics and study procedure of C-LACE study will be revised at Birmingham Women’s Hospital.

Follow-up: the described follow-up protocol will be considered successful if participants’ retention were ≥ 80%. The participant will be considered as lost to follow-up, if the participant could not be contacted and the patients file and notes were not reviewed.

Analysis and sub-analysis of outcomes and success criteria of C-LACE pilot and feasibility study will be made to explore the reasons of unsuccessful.

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