Background information will be collected from each participant using the baseline form. This information is required for interpretation of the data and dissemination.

Following the collection of the data from all forms (screening, consent, baseline, eligibility reassessment, operation, discharge, follow-up interview, 6-week record check) will be filled, signed and shared via the secure system; this system can be accessed at the university and the hospital and ensures the security of data, any data, entered will be anonymised.

The study has two parts: part A, which is blood and adipose tissue sampling for cefuroxime concentrations; part B, is a follow-up of patients’ post-partum at between 30 and 40 days to record the incidence of post-surgical infection.

The clinical care team will record the time of cefuroxime administration, dose administered, type of anaesthesia used, blood loss and other relevant clinical information. Five samples will be collected: 1 blood sample at time of skin incision, 1 blood sample at time of skin closure, 1 blood sample at recovery room (< 3 h following CS), 1 adipose tissue sample (approximately 1 cm from the skin in the middle of the Pfannesnstiel or vertical midline incision) at skin incision and one adipose tissue sample (from a similar location to sample 1) just prior to skin closure.

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