Descriptive statistics and Pearson correlation analysis were performed to determine correlations (r) between ADAMTS13 and VWF levels measured with the different test methods. In order to investigate the extent of degradation of VWF by rADAMTS13 in the ex vivo VWF cleavage experiments, paired t-tests were used to compare VWF:CB assay data (10 samples) and relative VWF dimer content from semi-automated electrophoresis gels (8 samples) at baseline and after 5 h of incubation with 1 IU/mL rADAMTS13. All the statistical analyses were performed using Minitab version 18.1.

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