The chemical compositions of HLJDT were collected from the Traditional Chinese Medicine Systems Pharmacology database (TCMSP, (Ru et al., 2014), which is a unique database platform of Chinese herbal medicine system pharmacology for capturing the relationship among drugs, targets, and diseases. Those meeting the criteria of bioavailability (OB) ≥30% and drug-likeness (DL) ≥0.1 (Xu et al., 2012) were used for further analysis. The HPLC chromatogram of HLJDT obtained from the methanol extract of HLJDT is shown in Supplementary Figure S1. The potential gene targets of the major compounds in HLJDT were searched from the TCMSP and PubMed databases. Totally, 448 HLJDT-related targets were obtained (Supplementary Table S2).

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