Cancer biopsies were obtained from patients with EOC admitted to the Second Hospital of Hebei Medical University from 2010 to 2013. All patients were confirmed by pathology and had complete clinic data and were followed up to 5 years post-surgery. Exclusion criteria: patients receiving endocrine therapy within the last 1 year, including oral contraceptives; Patients with primary malignant tumor combined with other systems; Patients with severe systemic infection, hyperthyroidism, hypothyroidism and other endocrine diseases. All samples were embedded in paraffin and incorporated into tissue microarrays by Shanghai Outdo Biotech Co., Ltd. There were 87 tissue cores with a diameter of 1.5 mm in a microarray block. The microarray included tissues from patients with papillary serous carcinoma (PSC, N=48), endometrioid ovarian carcinoma (EMC, N=6), mucinous ovarian carcinoma (MUC, N=12), clear cell ovarian carcinoma (CCC, N=4) and adjacent normal tissues to tumor (para-cancerous tissues, Para-ca, N=17). All samples involved in the study were obtained from perimenopausal or postmenopausal women. The patients' characteristics are shown in Table Table11.

Patient characteristics (N = 87)

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