GSEA analysis was used to further understand AURKA-related as well as FAM83A-related pathways. AURKA and FAM83A expression levels were used to grouping the LUAD patients in an independent TCGA cohort, samples with the expression levels were higher than the median value of both AURKA and FAM83A expression were assigned to the high expression group, rest of the samples are defined as low expression group automatically. The collection of annotated gene sets of c2.cp.kegg.v6.2.symbols.gmt was used to the reference gene sets and GSEA software was used to preform GSEA analysis. The cut-off criterion is FDR< 0.01.

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