All statistical analyses were performed using SPSS software, Chicago, IL, USA (version 23.0). Intergroup comparison (associations between PD1/PDL1-positive expression, CD8/CD68-positive cell density, and MSI/MSS) was conducted using the χ2 test or Fisher's exact test. Kaplan-Meier analysis was used to evaluate the significance of different factors in determining overall survival. Multivariate Cox regression analysis was performed using SPSS software. P-values were determined using the log-rank test. P <0.05 was considered statistically significant.

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