One author (F. Chen) extracted the main characteristics including trial name and its sample size, patients' median age, treatment regimens, and primary endpoints. Another author (N. F. Chen) confirmed the results. If relevant articles reported the same cohort of patients, only the update results were considered. If the same endpoint was evaluated by both independent review committee (IRC) and researchers, we extracted the data evaluated by the IRC. A senior reviewer (J. W. Cui) would make a final decision if there was any disagreement.

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