We included studies that met the following criteria: (1) involved patients with cytological or histologically confirmed HER2-positive breast cancer; (2) compared two or more treatments in second-line setting for trastuzumab-treated HER2-positive breast cancer; (3) reported endpoints: progression free survival (PFS), and (or) overall survival (OS); (4) were designed as RCTs. Articles or abstracts that did not meet any above criteria were excluded.

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