The checkerboard method was used for determining synergy of IBG with conventional antibiotics (Falagas et al., 2019). The interaction between two compounds was defined as synergy if FICI < 0.5, addition if 0.5 ≤ FICI ≤ 1, no interaction if 1 < FICI ≤ 4, antagonism if FICI > 4.

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