No extra tests are required for the trial but a case report form should be completed at the end of the 12- day treatment, or at death or hospital discharge if either happens sooner. The GOSE and the neuropsychological evaluations will be performed one month and 6 months after the TBI. Both evaluations will be performed by clinical neuropsychologists, and the protocol used will always follow the same process. The neuropsychological tests that will be performed are described in the Supplemental data.

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