The EPM test was used to assess the anxiety-like behavior in rats, 4 h after the last administration of PEAC according to the procedure described by Lister [38]. The animals were placed individually at the center of the maze with its head facing an open arm and allowed to explore the maze for 5 min. The parameters measured were frequency and duration of arm entries. An entry was scored when the four paws of the animals was completely be into one arm of the EPM. Ethanol solution (10%) was used to clean the plus maze after each test [38].

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