The effect of peel extract of Ananas comosus (PEAC) on spatial working memory of normal diet and high fat diet-fed rats were assessed using the Y-maze paradigm as previously described [36]. They were placed individually at arm A of the Y-maze and allowed to explore all the three arms freely for 5 min. The number and sequence of arm entries were recorded and the apparatus was cleaned after each test with 70% ethanol to remove animal clue. An entry was scored when the four paws of the animals were completely in the arm of the Y-maze. The percentage alternation, which is a measure of memory function, and was calculated by dividing the total number of alternations by the total number of arm entries, subtracted by two, and then multiplied by 100 [36].

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