The transcriptome profiles of 374 HCC samples and 50 cases of liver tissue adjacent to the tumor were obtained from The Cancer Genome Atlas (TCGA) database (https://portal.gdc.cancer.gov/). The clinical information including age, sex, vital status, TNM stage, and histological grade of the corresponding patients was obtained and assessed. Samples with overall survival (OS) less than 30 days were excluded from nontumorous death factors, including infection.

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