Specific statistical tests used for each analysis are specified in the figure legends. Spearman’s correlation analysis was used to test the association of signaling protein phosphorylation with disease activity. The two-sample Wilcoxon’s rank sum test and non-parametric Kruskal-Wallis test were adapted to test the difference in signaling responses between HC vs RA patients or multiple groups with GraphPad Prism 7, if applicable. P-values <0.05 were considered statistically significant.

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