We will analyze the data with RevMan software (Version 5.3) (Available at: https://community.cochrane.org/help/tools-and-software/revman-5) provided by The Cochrane Collaboration.[18]A meta-analysis using random or fixed effects models will be conducted to summarize the data. Continuous data will be pooled and presented as mean differences or standardized mean difference with their 95% CI. Dichotomous data will be pooled and expressed as risk ratio with their 95% CI. We will interpret it using the following criteria: I2 values of 25% is considered low levels of heterogeneity, 50% indicated moderate levels, and 75% indicated high levels.[19] Since low or moderate heterogeneity suggests little variability among these studies, the data will be analyzed in a fixed-effects model.[20] When significant heterogeneity occurs among the studies (P < .05, I2 > 50%), a random-effect model will be performed to analyze the data.

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