We used an accurate binomial test to calculate the required sample size. According to the previous randomized control studies and meta-analyses, the threshold for the histological accuracy rate with a standard FNA or FNB needle with a reverse bevel was 77%. We assumed the diagnostic accuracy of histology with this needle to be 90%. To achieve a statistical power of 0.80 for exact binomial tests with a 2-sided type-I error of 0.05, our minimum sample size was 60 patients. Since we expected some patients to be nonevaluable, we considered enrolling 70 patients.

We expressed out results as numbers and percentages for categorical variables or as medians and ranges for continuous variables. For the analysis of overall diagnostic yield, Clopper & Peason exact confidence interval was used for binary outcome. We considered a P< .05 as statistically significant. We used the SAS software version 9.4 (SAS Institute, Cary, NC) to perform all the statistical analyses. The final clinical data obtained with follow-ups until March 2019.

Note: The content above has been extracted from a research article, so it may not display correctly.



Q&A
Please log in to submit your questions online.
Your question will be posted on the Bio-101 website. We will send your questions to the authors of this protocol and Bio-protocol community members who are experienced with this method. you will be informed using the email address associated with your Bio-protocol account.



We use cookies on this site to enhance your user experience. By using our website, you are agreeing to allow the storage of cookies on your computer.