For sensitivity and specificity (KQ 1) and diagnostic impact outcomes (KQ 2), we will accept any reference standard tests adopted in eligible studies. However, we will prefer clinical verification including repeat and/or additional imaging, surgical or radiological interventions, and clinical follow-up and autopsy, if performed, as the appropriate clinical reference standard over WBCT (performed as the index test) only. Likewise, we will accept any methods to verify event-type and duration-type clinical outcomes for KQs 4–6; however, we will record whether a study prospectively identified the events or durations through research-oriented, study-specific methods (preferred), or relied on data, routinely collected for purposes other than research such as data from disease or trauma registries, or medical charts.[40]

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