Interventions in the experimental group are “trifluridine and tipiracil” monotherapy, while the control group are placebo. Patients received oral trifluridine/tipiracil 35 mg/m2 twice daily plus best supportive care or placebo twice a day plus best supportive care on days 1–5 and days 8–12 of each 28-day treatment cycle, and the course of treatment is more than or equal to 2 cycles.

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