Two experienced authors (Shuxia Ge and Qianqian Xing) will be reviewed independently to identify potential trials by assessing the titles and abstracts. The full text will be further reviewed to determine potential eligible studies. A PRISMA-compliant flow chart (Fig. (Fig.1)1) will be used to describe the selection process of eligible trials. Excluded studies and reasons for exclusion will be recorded. Endnote X7 software will be used for literature managing and records searching. Disagreements between the 2 researchers will be resolved by consensus or by a third independent investigator (Anqi Zhang).

Study selection process for the meta-analysis.

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