Randomized controlled trials (RCTs) or prospective controlled clinical trials that investigated the efficacy of TCM on survival, QoL, tumor markers, and immune function in patients diagnosed with OC will be included in this systematic review. There will be no restrictions for blinding, population characteristics, and duration of trials.

Patients with histologically proved OC were included in this study. No restrictions regarding age, gender, racial, region, education, and economic status were reported. Patients with other malignancies are not included.

In the experimental group, OC patients must be treated with TCM alone or in combination with other conventional treatment methods, including surgery, radiotherapy, chemotherapy, and so on. TCM involving extracts from herbs or insects or animals, single or mixture formulas regardless of their compositions or forms. There will be no restrictions with respect to dosage, duration, frequency, or follow-up time of treatment.

There will be no restrictions with respect to the type of comparator. The comparators are likely to include surgery, radiotherapy, chemotherapy, supportive care, and other therapeutic methods.

Overall survival (OS), the time from the date of randomization to death from any cause;

QoL obtained from the corresponding scale;

Immune function indicators: CD3+, CD4+, CD8+, NK cells percentage, CD4+/CD8+ cell ratios, and serum cytokines level (IL-2, IL-4, IFN-γ, TNF-α, and so on).

Overall response rate (ORR) and disease control rate (DCR);

Tumor markers: HE4, CA125, CEA, and CA199;

Adverse effects: Gastrointestinal adverse reactions, leukopenia, hepatorenal toxicity, and so on.

Duplicated studies, papers without sufficient available data, noncomparative clinical trials, literature reviews, meta-analysis, meeting abstracts, case reports and series, and other unrelated studies will be excluded from analysis.

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