The model described above allows to test the impact of various relevant parameters, thereby generating a range of possible physical environments relevant for HIPEC treatments. We tested the impact of various parameters for the largest tumor model, 4mm in size. Parameters introduced in the introduction are size, concentration, velocity and temperature. The first environment we considered was the baseline case, with baseline temperature, fixed concentration and fixed velocity. Baseline simulations were executed for all geometries. Baseline parameters are listed in the last four rows of Table 2. The baseline concentration was calculated using a clinical cisplatin dose of 120 mg/m2 and a perfusate volume of 2 L/m2, both common in clinical settings (Helderman et al., 2019). Baseline temperature was chosen to be 42°C (Helderman et al., 2019). The relevant flow velocity range was based on velocities known to be present during HIPEC treatments. The minimal velocity is near zero and the maximal velocity can be found directly behind the inflow catheter. Using the inner-radius of 3.1mm for a standard Tenckhoff catheter (Ash, 2003) and a volumetric flow rate of two liter per minute we found a maximal velocity of vmax 1.1 m/s, being the inflow velocity. The different cases considered in this study are listed in Table 3.

Definition of cases featured in this study. Cases are named after the parameter being tested, listed in the first column.

The parameters were only tested on the largest tumor model, 4mm in size. The maximal clinical flow velocity was calculated to be vmax1.1 m/s.

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