Statistical analysis was performed with Prism 6 (GraphPad software). For better comparison among different groups, data acquired in each cell were normalized to the value under control condition. The Kolmogorov–Smirnov (KS) test was used to compare the cumulative distributions of data. Differences between experimental samples were assessed for significance using two-tailed Student’s t test, Wilcoxon signed-rank test or Mann–Whitney test where appropriate. Significance was taken as p < 0.05. All data were illustrated as mean ± SEM.

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