The primary endpoint of this study was OS, which was measured from the date of initiation of first-line chemotherapy to the date of death as a result of any cause or last date of follow-up. The objective of this study was to develop and validate a prognostic model allowing patients with de novo mNPC to be stratified based on their survival expectations. In the current study, variables of interest were selected based on a review of the literature. All variables included in this study were supposed to be underlying prognostic factors or confounding factors involving demographic information, clinical characteristics, tumor features, and treatment-related factors.

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