S. cerevisiae CMCC17452 was cultivated with YPD broth (Becton, Dickinson and Company, Sparks, MD, USA) at 28 °C for 48 h. P. notoginseng root (PNR) and pure water were were mixed to a ratio of 1 to 10 before sterilization for 15 min at 121 °C. S. cerevisiae CMCC17452 was inoculated into PNR solution at a concentration of 5% (V/V) and fermented at 28 °C for 24 h. The PNR solution without S. cerevisiae CMCC17452 was used as a blank control. Samples were centrifuged and the supernatant collected for analysis and named fermented P. notoginseng root liquid (FPNR) and water-extracted P. notoginseng root liquid (WPNR).

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