We retrospectively reviewed 14 children with unilateral RB and intracranial segment of retrobulbar optic nerve invasion from January 2009 to December 2018. The inclusion criteria were as follows: 1) Patients diagnosed with unilateral RB for the first time in our hospital; 2) patients with orbital magnetic resonance imaging (MRI) before chemotherapy suggesting invasion of the intracranial segment of retrobulbar optic nerve; 3) patients with age < 14 years; 4) patients undergoing chemotherapy, radiotherapy, surgery, intrathecal therapy and follow-up according to comprehensive treatment of our hospital. The exclusion criteria were as follows: 1) patients with trilateral RB; 2) patients with recurrent invasion of the intracranial segment of the optic nerve after treatment; 3) patients with distant metastasis of bone, bone marrow and lymph nodes at the time of diagnosis; 4) patients with severe congenital deficiency, including immune deficiency, liver and kidney patients, etc.; 5) patients with a family history of mental illness; 6) patients with a family history of RB. This study was approved by the ethics committee of the Beijing Tongren Hospital, Capital Medical University (number, TRECKY2019–034). Written informed consent was obtained from all participants and their guardians.

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