We performed a cohort study with prospectively collected data from the Information System for Research in Primary Care (SIDIAP; www.sidiap.org), from January 1, 2006, until December 31, 2018. SIDIAP includes routinely recorded information by health professionals from 287 primary care centers in Catalonia, a region in Northeastern Spain [11, 12]. SIDIAP contains anonymized records for approximately six million people (80% of the Catalan population) and is representative of the Catalan population in terms of age, sex, and geographic distribution [12]. It includes high-quality data on anthropometric measurements, disease diagnoses (International Classification for Diseases, 10th revision [ICD-10]), prescription and dispensation of drugs, laboratory tests, and demographic and lifestyle information. Further, SIDIAP is linked to the Minimum Basic Dataset (CMBD in Spanish), a population-based registry that includes hospital discharge information in Spain [13].

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