The methods for statistical analysis and sizes of the samples (n) are specified in the results section or figure legends for all of the quantitative data. All values are presented as mean ± s.d. with the indicated sample size. No samples were excluded from analysis. Statistical differences were determined using one-way analysis of variance (ANOVA) followed by the Tukey post hoc test for three or more groups. Statistics were performed using GraphPad Prism 8 and SPSS 24.

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