All oligonucleotides including staple strands, capture strands and aptamers were purchased from Integrated Invitrogen (Shanghai, China). The origami staple strands were stored in tubes with concentrations normalized to 100 μM, and were used without further purification. The concentration of each strand was estimated by measuring the UV absorbance at 260 nm. Thrombin from human plasma (T6884) was purchased from Sigma-Aldrich. Dialyzers (AEF-03) were purchased from AsahiKASEI. Unfractionated heparin (UFH, Changzhou Qianhong Bio-pharma Co. Ltd.) and low molecular weight heparin (LMWH, QILU Pharmaceutical Co. Ltd.) were obtained from the clinical laboratory of the second affiliated hospital of Xi’an Jiaotong University.

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