The primary disease event was in-hospital mortality. Discharge was analysed as a competing event by competing risks analysis.

The criteria for discharge were absence of fever, clinical remission of respiratory symptoms, oxygen saturation greater than 94% and two nasal swab samples negative for SARS-CoV-2 RNA obtained at least 24 h apart.

Septic shock was defined according to the 2016 Third International Consensus Definition for Sepsis and Septic Shock28. Acute kidney injury was defined according to the KDIGO clinical practice guidelines29 and acute cardiac injury was diagnosed if serum levels of cardiac biomarkers (troponin) was above the 99th percentile upper reference limit, or if new abnormalities were shown in electrocardiography and echocardiography30.

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