The smartpca algorithm implemented in EIG v7.2.1 was used to perform the Principal Component Analysis (PCA) for the PGx panels and the genome-wide panel25, 26. The program ADMIXTURE was used to estimate individual ancestry proportions. Supervised and unsupervised analysis were performed with three and four-population models27.

The relative performance of the PGx panels to estimate admixture proportions was evaluated by the correlation of individual admixture proportions (R2 values) obtained with the genome-wide panel versus those obtained with each PGx panel. We also evaluated the differences in mean ancestry proportions obtained with the genome-wide panel and each PGx panel.

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