All statistical analyses were conducted using the R software (version 3.6.3) ( and its corresponding R packages. The Area Under Curve (AUC) of ROC curve was performed using the survialROC R package. KM curve analysis was completed using log-rank test from survminer R package. GSEA analysis was completed using clusterProfiler R package. The c5.bp.v7.1.entrez.gmt file from the Molecular Signatures Database (MSigDB, /gsea/index.jsp) was obtained for the GSEA to identify biological processes. All P value of less than 0.05 indicated a statistically significant difference in all analysis.

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