The neu exon deletion line (NDL), a syngeneic model of mammary adenocarcinoma, was obtained from the Alexander Borowsky Laboratory (UC Davis, Davis, CA). Four-week-old FVB/n female mice purchased from Charles River (Wilmington, MA) were transplanted with NDL tumor biopsies (~ 1 mm3) bilaterally into the fourth and ninth inguinal mammary fat pads. Approximately 21 days later, when tumors reached ~ 4 mm in longest dimension, mice were randomized into treatment groups.

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