The primary outcome was CVD defined as any first event of the following: acute myocardial infarction, unstable angina, either ischemic or hemorrhagic cerebral stroke, congestive heart failure, symptomatic arrhythmia, aggravated valvular heart, pericardial disease, abdominal aortic aneurysm, and severe peripheral arterial disease that required hospitalization, intervention, or therapy during the follow-up. The secondary outcome was a composite of CVD and all-cause death. For the present study, data were collected until drop-out, death, or March 31, 2018, whichever came first.

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