The diagnostic criteria were grouped according to the extent to which the importance of PEM and other core symptoms, including pain, sleep disturbances, cognitive impairment and neuroendocrine dysfunction is emphasized [52]; CF: “No PEM” (PEM is not mentioned as a criterion), CFS: “Optional PEM” (PEM is included as an optional or minor criterion) or ME: “required PEM” (PEM is a required or main criterion). The categorization of the diagnostic criteria sets is presented in Table Table11.

Diagnostic criteria classification with respect to the significance of PEM and other core symptoms

aRequires exercise-induced fatigue, but does not require presence of all core symptoms;

bNo PEM required (may be post-exertional fatigue) and does not require presence of all core symptoms;

cPost-exertional neuroimmune exhaustion (PENE)

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