Agreement in MRI evaluation between the 2 readers was calculated using the intraclass correlation coefficient (ICC). An ICC value >0.75 represented good to excellent agreement. Data from the 2 readers was averaged for analysis. The global R2*, global FF, and clinical parameters between patients with elevated and normal fasting glucose were compared using the Mann-Whitney U test or Chi-square test. Box and whisker plots were used to display the differences in the global pancreatic R2* and FF in patients with normoglycemia versus patients with IFG. The Friedman test was used to compare R2* and FF among the 3 different regions of the pancreas, and differences between subgroups were determined using the paired Wilcoxon-Mann-Whitney test. Scatter plots were generated to show the correlations in R2* and FF among the 3 pancreatic regions. Linear regression analysis was performed to further test the relationship of R2* among the 3 different pancreas regions in patients with mild to moderate pancreatic IO. Correlations among the biochemical parameters, global R2*, and global FF were determined using Spearman’s correlation analysis. Receiver operating characteristic (ROC) analysis was used to determine the performance of global pancreatic R2* and global FF for discrimination between patients with normal and impaired glucose function. The Youden index determined the optimal threshold. All statistical analysis was performed in SPSS (version 13.0, SPSS Inc., Chicago, IL). A two-sided P value of less than 0.05 was considered statistically significant.

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