Between May 2015 and January 2016, 99 consecutive outpatient children with TM were enrolled. The institutional review board approved this prospective study of Sun Yat-sen Memorial Hospital of Sun Yat-sen University (No: 2013-19). Written informed consent was obtained from all patients or their parents. All patients were diagnosed with TM by genetic analysis. Patients were excluded if they were overweight, defined by body mass index (BMI) exceeding the normal reference line (21), or had a family history of diabetes. Two overweight patients and 1 patient with a family history of diabetes were excluded. Additionally, 6 patients with obvious motion artifacts on MRI were also excluded. Finally, 90 children (mean age, 10.7±3.1 years; age range 5.0–17.5 years) consisting of 64 boys (mean age, 10.5±3.1 years; age range 5.0–17.0 years) and 26 girls (mean age, 11.3±3.0 years; age range 6.0–17.5 years) were included in this study.

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