CT and MRI examinations for all patients were performed before radiotherapy, and the interval between CT and MRI scans was less than 2 weeks. All patients fasted for 4–8 hours before examinations. CT images were obtained using a 64-multi-detector CT scanner (LightSpeed VCT, GE Healthcare, Waukesha, USA), with supine position and head-first. The time points for the arterial, portal, and delayed CT scans were 35, 70 and 180 s after the injection of Omnipaque (350 mgI/mL, GE Healthcare, Shanghai, China), respectively. 80–100 mL omnipaque was intravenously injected at a rate of 3.0 mL/s followed by 50 mL saline flush using a power injector (Medrad Stellant CT Injector System; One Medrad Drive Indianola, PA, USA). Plain and Portal were defined as CT scans before and 70 s after the injection of Omnipaque, respectively. The slice thickness for CT images was 5 mm.

MRI images were acquired using a 3.0-T MRI scanner (Ingenia, Philips Medical Systems, Best, the Netherlands) with a 16-channel phased-array body coil in supine position and head-first. mDIXON sequence (water, fat, in-phase, and out-phase images) with 2 mm slice thickness was used to obtain T1-weighted images. Gd-EOB-DTPA (Primovist; Bayer HealthCare, Berlin, Germany) was used for enhanced MRI protocol. Three-arterial-phase images (early arterial phase, middle arterial phase, and late arterial phase) were acquired at 20 s after the intravenous administration of Gd-EOB-DTPA (0.025 mmol/kg), and each arterial phase was 6 s. Gd-EOB-DTPA was injected at a rate of 1.0 mL/s, followed by 15 mL saline flush with a same speed using a power injector (Medrad Spectris Solaris EP MR Injector System; One Medrad Drive Indianola, PA, USA). Portal phase images (EOB 70 s), delayed phase images, and hepatobiliary phase images (EOB 15 min) were acquired using mDIXON sequence at 70 s, 180 s, 15 min after the injection of Gd-EOB-DTPA, respectively. A single shot echo-planar imaging (SS-EPI) DWI with b values of 0, 800, and 1,000 s/mm2 was acquired, and the slice thickness was 6 mm. DWI image with b value of 1,000 s/mm2 was used for GTV delineation.

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