For each comparison with 10 or more studies, we will visually assess publication bias and small-study effects using funnel plots (using study’s effect estimates for the primary outcomes against their standard errors). We will utilize GRADE approach to determine the quality of evidence of included articles, designating all articles to one of four levels of evidence according to their study and other variables which have the potential to impact the quality of evidence (such as indirect evidence, specific types of bias, and effect size) [28].

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