We computed the vertex-based high-resolution connectome using streamlines reconstructed by tractography and vertices from the cortical surface meshes. We manually checked that tracks and mesh were properly aligned (see Suppl. Figure 1A), for distance between track bounds and nearest cortical surface mesh (see Suppl. Figure 1B). Intersections between the streamlines with FreeSurfer’s cortical surface mesh templates were assessed using the coordinates of two points of the tracks at each bound (see Suppl. Figure 2). If an intersection was found for each bounds i and j, the connection weight Ci,j between the vertices nearest to the intersection points is incremented by 1. Otherwise, if for one or both bounds the track was too short to reach the surface mesh (no intersection point), a linear extension of 3 mm using the direction defined by linearly interpolating the bound and the third last coordinates from the bound was added to the track, and the intersection was assessed again. If no intersection is found in one or both bounds even after extension, the track is discarded. Length of track bound and size of the extension are adjustable parameters, and several cortical meshes are available using white-matter gray-matter boundary (WMGM) or gray matter (pial) surfaces.

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