Ethics approval was obtained from the Royal Brisbane and Women’s Hospital Human Research Ethics Committee, ref. number HREC/2018/QRBW/43155, and from Kowloon Central/Kowloon East and New Territories East Cluster ethics committees (ref: KC/KE-17-0173-FR-2 and CREC:2017:563). The protocol complied with the Declaration of Helsinki and the ICH-GCP.

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