Both the primary and secondary outcomes will be analyzed by logistic regression, controlling for three, prespecified, potential confounding variables, i.e., age, sex, and subtype of IBS. The difference between study groups will be considered significant when the p value is < 0.05, when the 95% CI for RR (or odds ratio [OR]) does not include 1.0, or when 95% CI for MD does not include 0. All statistical tests will be two-tailed and performed at the 5% level of significance.

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