Functional annotation and enrichment analyses of DEGs were performed using Database for Annotation, Visualization and Integrated Discovery (DAVID) Bioinformatics Resource 6.8 tool (https://david.ncifcrf.gov/) [31] with DAVID-defined default annotation categories. Enrichment analysis of Gene ontology (GO) was performed to identify and categorize enriched biological process, molecular function and cellular component. In addition, DEGs were also searched against the Kyoto Encyclopedia of Genes and Genomes (KEGG) database to detect significantly enriched pathways.

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